Abstract: Regional climate change in China under the IPCC A2 scenario was simulated for a 10year period by MM5V3, using the output of an IPCC A2 run from CISRO Mark 3 climate system model as lateral and surface boundary conditions. The regional climate change of surface air temperature, precipitation, and circulation were analyzed. The results show that the distribution of mean circulation, surface air temperature, and precipitation were reproduced by MM5V3. The regional climate model was capable to improve the regional climate simulation driven by GCM. The climate change simulation under the IPCC A2 scenario indicates that future surface air temperature in China would increase, with a stronger trend in winter and a south-north increasing gradient. Surface air temperature would increase more than 1℃ over Northeast and Northwest China, whereas climate change would distinctly alter precipitation distribution. Annual mean precipitation would remarkably increase in Northeast China, Yangtze Huaihe River Valley and the south area of the Valley, while rainfall would appear a decreasing trend in partial areas of North China and many regions of Southwest and Northwest China. The precipitation simulation show different changes in different seasons and regions. Future climate change indicates an increase of precipitation over North and South China, and Yangtze Huaihe regions, precipitation in autumn and a decrease in winter.