Abstract: Body Perception of Weather Index (BPWI) is the degree to which the human body perceives the synergistic effects of different weather elements in the atmospheric environment. Changes in BPWI can cause physiological stress in the body, which can induce or aggravate the occurrence of cerebral infarction (CI) disease. The effect of BPWI changes on the CI risk is studied using the relationship between daily CI inpatients and BPWI during the same period from 30 October 2015 to 31 December 2018 in Wuchang region. The results show that the maximum value of BPWI in Wuchang area is 10.1 (July) and the minimum value is −33.7 (January) in the whole year. The CI risk is higher when BPWI <0 and the number of CI inpatients accounts for 16.7% of the total cases when BPWI is between −30 and −10. The highest incidence accounts for 18.8% when BPWI <−30 and 12%—13% when BPWI is between 0 and 10, and the incidence is the lowest when BPWI >10. Compared with that during the same historical period, the average CI incidence is 20% greater when the change in BPWI ranges from 0 to −10, the highest incidence of 27.6% occurs when the change ranges from 0 to −2.5, and the incidence decreases when the change exceeds ±10. The change in BPWI on 2 consecutive days has a lagged effect on the CI onset, which shows an average percentage increase greater than 25% with BPWI changes between −2.5 to 2.5. The change in BPWI on 3 consecutive days has a cumulative superimposed effect on CI risk, which shows a percentage increase within the range of 13%—18% when BPWI change is between −10 and 10. The difference between indoor and outdoor BPWI has an important influence on the CI incidence, and the highest incidence is 41.3% when the difference is between −30 and −20, followed by 21.6% when it is between −40 and −30. However, the CI incidence gradually decreases when BPWI is <−40 or when the difference between indoor and outdoor BPWIs decreases.